منابع مشابه
Nalidixic acid: an antibacterial paradox.
Nalidixic acid was found to be most bactericidal against various species of gram-negative bacteria at 50 to 200 mug/ml. With all species tested, increases in the concentration of nalidixic acid above this range reduced, rather than increased, its bactericidal effect so that, at levels in the region of 400 mug/ml, the drug was relatively bacteriostatic. Therefore, the mode of action of nalidixic...
متن کاملPhotochemical Reaction of Nalidixic Acid in Methanol
The photochemical reactions of methanolic nalidixic acid (NAL) solution in the absence and in the presence of air have been investigated using 300 nm UV light. From the reactions, 1-ethyl-7-methyl-4-oxo-4-hydro-1,8naphthyridine (EMDN), formic acid, and formaldehyde are produced. In the presence of air, hydrogen peroxide is also detected along with the products listed above. The presence of oxyg...
متن کاملConvulsions and hyperglycaemia associated with nalidixic acid.
Hyperglycaemia and convulsions in patients taking nalidixic acid are usually associated with overdosage of the drug or an underlying epileptic tendency.' :1 Nalidixic acid may also interfere with biochemical determinations of plasma and urinary glucose, giving falsepositive results. We describe an otherwise healthy patient who had convulsions and hyperglycaemia (confirmed by a glucose-specific ...
متن کاملAcute intracranial hypertension after nalidixic acid administration.
Nalidixic acid (Negram) is an antimicrobial agent widely used in the treatment of urinary tract infection. Some years ago Boreus and Sundstrom (1967) reported intracranial hypertension in a 6-month-old boy treated with nalidixic acid at the manufacturer's recommended dose. Only a few cases have been reported since, mostly in children treated either with large doses (Fisher, 1967) or for prolong...
متن کاملNalidixic acid-resistant auxotrophs of Escherichia coli.
purB and ctr mutants of Escherichia coli are resistant to low levels of nalidixic acid.
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ژورنال
عنوان ژورنال: BMJ
سال: 1981
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.282.6259.224